844 North New Ballas Court, Suite 300
St. Louis, MO 63141
Phone : 314 473 1285
Fax : 314 473 1287
After Hours : 314 277 8782

..where everyone has a chance to start a family

Marc & Hilary


After 2 years of trying to conceive naturally and without any luck, my husband and I came to Dr. Jacob’s office. We were not sure if we would ever have the baby that we wanted so badly. After a month of testing we found out why I wasn't conceiving and decided to try IUI. I was in fact pregnant after the first try. Unfortunately, it wasn't a good pregnancy and I ended up miscarrying. The miscarriage process was awful, but the staff at Dr. Jacobs was so caring and went out of their way to help us through the difficult proces......

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Charlotte, Eli and Noah


So excited



Robert and Alyssa



"We still cannot thank you all enough for helping us carry out our dream of becoming parents! It is truly the most amazing feeling ever. God Bless!"



Renee and Mike


"Words cannot express how much Dr. Jacob and his staff mean to me and my family. They are one of a kind, giving me the great treasure I could have ever dreamed of. He gave me my little miracle, my Amelia. Thank you Dr. Jacob for all you do. Keep creating miracles and making families, because you made mine 1000 times better. Thank you, thank you, we all love you."
Renee and Mike   



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Barbara and Yolanda


Thank you, thank you, THANK YOU!



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Jennifer and Bill


"Everyone in the office was very caring, friendly and professional. Most importantly, we got the results we were looking for."


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Jeri & Aaron


Words truly can not express how truly wonderful the CRMS facility and staff are! Not only is Dr. Jacob incredibly knowledgeable and passionate about what he does, but he truly cares about his patients and is incredibly compassionate. You become part of their "family" when you are patient there and TOGETHER you go through the emotional struggle that infertility so often causes. Dr. Jacob and his staff is there with you every step of the way offering guidance, support, and expertise. They are always there when you have questions, con......


Deb & Andrej


It is with joy that I write this testimonial about the "Center". Today, with Oliver on our arms, we forget all the hard days in the past. It was all worth it.  And this dream wouldn't have been possible if it wasn't for Dr. Jacob's knowledge and the love and compassion of his wonderful staff. Sorry to the other great families out there, but Ollie is Dr. Jacob's true "masterpiece".



Bryan & Emily


"Our dreams of being parents have finally come true. Without the expert advice from Dr. Jacob and support from his staff, we wouldn’t get to hold our sweet baby girl each and every day. We have been through struggles, heartache, and triumphs with CRMRS and everyone was there for us when we needed them most. The bond we have made with everyone in the office will forever be in our hearts. Thank you so much for your love and support on our journey to parenthood. Much love"
Bryan and Emily


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Karen & Dean


"We cannot thank Dr. Jacob and the entire staff enough for our little miracle! Working with everyone at CRMRS was a wonderful experience. The entire staff truly cares about their patients. Dr. Jacob never gave up hope for us to have a baby and did everything he could to help our dreams come true. The CRMRS staff is like family to us, and we highly recommend working with them to help your dreams of a family come true! "
Karen and Dean


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Ganesh & Cher


Thanks again for all your help in making our miracle!
-Ganesh & Cher


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Teresa & Colan


I would like to thank Dr. Jacob and his wonderful staff for our little miracle, Princess Skylar. This has truly been a blessing to my family. Thank you again.


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Melissa & Luis


Thank you again to Dr. Jacob for all the help and support.  These babies are truly a
Melissa and Luis


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Tacy & Martin


"Thank you so much from the bottom of our hearts for helping make these blessings possible. You all were so great to work with and made the process that much better!" 
Tacy & Martin


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Erica, Kari & Griffin


After speaking with other medical facilities and finding out we would have to wait months to be seen we found Dr. Jacob's office.  When I called his office I spoke to Ashley and right away she was more than compassionate.  She explained all of the options and timelines and knew exactly how handle us during that stressful time.  Being a same sex couple we always felt welcomed and that the whole staff was rooting for us!  We met with Dr. Jacob and set-up a plan right away.  After a few tests were completed  we......

(858) 771-9450

Rich & Amanda


After trying to conceive for several years, my gynecologist recommended Dr. Jacob for a consultation.  Dr. Jacob and his team are amazing!  Dr. Jacob always took the time to sit down with us, answer our questions, and educate us.  We developed a fertility plan, trying IUI first, then IVF later.  Dr. Jacob was always honest with us, but he remained optimistic and was determined to help us achieve a pregnancy! With a change to our approach to one IVF cycle, as recommended by Dr. Jacob, we were overjoyed to learn I was pregn......


Tim & Heather


Our journey began in 2010 after a surgery to remove both of my tubes meant that I could only get pregnant through IVF. Dr. Jacob was recommended by a nurse at another Dr’s office. He was great from the beginning by the process and what to expect. It felt intimidating, but his office really helped break things down into not so complicated steps. We always felt very comfortable with him and his staff. Our first round of IVF produced 5 embryos. They put the two best embryos in during the transplant (and froze the remaining three) and we f......

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Jared & Alis


After trying for two years to get pregnant, we were referred to Dr. Jacob by my gynecologist. Upon arriving at the clinic we were very nervous and did not know what to expect. I was so happy to see that the office manager, Ashley, was working here and I had known her previously which eased my mind! Dr. Jacob has a wonderful, caring, helpful staff that is ready to answer any questions that we had. They make you feel like part of their family and we will always have a special place in our heart......

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Angela & Jeremy


I have many things to thank Dr. Jacob for so where better to start then the beginning. Since the day I became a woman I have had issues with my cycle and more pain with every year that passed. I have seen 15 doctors before being introduced to Dr. Jacob and they all told me the same things. They said it was hereditary, all in my head, that I just needed to get used to the pain or they could put me on a birth control pill. In October of 2007 I met with Dr. Jacob and after the first 15 minutes of going over my history he handed me information o......


Lesley & Clinton


After eight years of struggling with infertility and several other doctors, we walked into Dr. Jacob’s office and never looked back. The superb medical professionalism goes without saying but it is difficult to put into words just how much compassion is also offered. He and his staff give you such hope that your dreams of a family will come true. Our sweet baby boy was born thanks to their superior care. Infertility is honestly the hardest fight my husband and I have had to face but with CRMRS in your corner you can wake up every day k......


Angie & Mickey


"My husband and I just wanted to express how grateful we are to have met Dr. Jacob. After suffering a tubal pregnancy and struggling to get pregnant we knew it was time to get professional help. I was referred to Dr. Jacob by my doctor and we were so happy we did not wait any longer. From day one the entire staff was extremely supportive, caring and always available.  Dr. Jacob made us feel comfortable and always explained any questions or concerns we had in detail. I knew after the first couple visits I was not just another patien......


Ellen & Justin


I am so thankful our doctor recommended Dr Jacob's office. We had a great experience! The staff was just amazing. They really took the time with us. Dr. Jacobs was great. He was very thorough and had a fertility plan for us very quickly. They didn't waste any time and we were doing IVF within a couple months. It worked on the first try! We were having twins! I did get sick along the way and have to be hospitalized. All of them came to visit and were so supportive! I had a healthy pregnancy and gave birth at 36 weeks. We would not be ......

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Brian & Nicole


Our infertility was an intense emotional roller coaster.  We went to a specialist, and was told by his nurse there was no chance of us conceiving our own child.  We struggled with this for a long time.  We did not want to give up.  Then one day we found our miracle workers at Dr. Jacob's office.  He and his staff are completely devoted and compassionate to us during the whole process.  They gave us hope!!  Dr. Jacob was positive yet realisitic with our chances for conceiving.  He made us believe it......

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Steve & Holly


"The more people we talk to the more we find out how many people are having trouble.  We have your numbers handy and will continue to recommend you guys to anyone who is looking for a fantastic fertility place. :-)"
Steve and Holly


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Stacy & Steve


" My husband and I tried to conceive for over two years when an OR nurse who had worked with Dr Jacob recommended him. The consultation with Dr Jacob was easy to set up, and we felt welcome immediately upon arrival. His staff was courteous, professional and genuinely concerned about our well being during the entire process. Dr Jacob was willing to listen to every concern we had and investigate those concerns at length. Dr Jacob took the time to explain the whole process in a language we could understand. We were always well informed abo......


Ronald & Chara


"Dr. Saji Jacob is the most honest and compassionate medical professional I know.  The passion he has for his work and the care he expressed during my procedure exceeded my expectations.  Dr. Jacob and his very caring staff inspired me during testing, diagnosis, treatment, and good news and not so good news.  They helped to relieve the stress of infertility.  The Center for Reproductive Medicine and Robotic Surgery is the best in the infertility field.  Ronald and I are very grateful to have been under the care ......

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Angie & Nathan


"Dr. Jacob and his staff helped us to understand, accept, and overcome our medical challenges.  After only one cycle, we were pregnant with twin boys, and they arrived nine months later!  Infertility is a tough thing to face, but Dr Jacob and his staff will go the extra mile to make sure you feel like you are not alone in this. They offer encouragement, answer questions at all hours of the day, and help you decide what options are the best for you.  We would highly recommend the Center for Reproductive Medicine & Robo......

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Steve & Michelle


"To describe our experience with Dr. Jacob and his staff at Center for Reproductive Medicine and Robotic Surgery is impossible to put into a short testimony. The gratitude my husband and I have for Dr. Jacob is beyond explainable. Dr. Jacob was the first doctor to sincerely care and listen to what we had to say. He did not hesitate for a minute to run the appropriate test to help us determine the cause of not being able to conceive a child. He is incredibly knowledgeable about the reproductive system and causes of infertility. Once we d......

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Kira & Brendan


"I was lucky to have met Dr. Jacob 10 years ago when he first diagnosed me with stage four endometriosis. I had been to other doctors who had miss diagnosed me, or told me that my pain was all in my head. I was scared, confused, and I didn’t know what was going on. I just knew that I was in severe pain and it wasn’t right.After meeting Dr. Jacob that first day, I knew he was going to help me, and he has. He has been such a blessing to my family and me. I haven’t always had it easy. I have gone through a lot of tests an......

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Ram & Sunitha


I have no words (speechless may be right word!!) to express my gratitude to Dr. Jacob and his staff and very thankful to God to have sent Dr. Jacob and his staff in my way to help me. Whatever I say, can be an understatement. Right from day one, Dr. Jacob was so helpful and clear in explaining  everything that is involved in the procedure. Everybody in his office were so kind hearted and very supportive, not to forget, even after hours. I would recommend Dr. Jacob to couple like us, since I found him, best in the business. Mainly, I see......


Sara & Adam


"We just wanted to say thank you from the bottom of our hearts to Dr. Jacob and all the staff at the Center for Reproductive Medicine and Robotic Surgery.  Since I was a young girl, I knew that I wanted children - I love everything that children bring to us in life and I especially love working with kids everyday as a grade school educator.  When I struggled to get pregnant, I worried that I might never be able to have the joy that having your own children brings and that hurt.  Dr. Jacob, you and your staff were phenomen......

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Ashley & Jimmy


"Hi, this is Ashley. I would like to share my story with all of you. Well here it goes. I was trying to conceive for 12 years and almost gave up. I decided to try IVF but I didn't have much hope because I had stage 4 endometriosis. I didn't know much about endometriosis until I went to Dr. Jacob. Dr. Jacob explained in great detail what endometriosis was. He is an amazing wonderful, doctor and the staff was great too. Because of my insurance, I could only go through this one time. The first time I tried it - it worked. I was ver......

We are very proud to announce our overall pregnancy per embryo transfer success rate for 2017 is 81.08%

Welcome to the Center for Reproductive Medicine and Robotic Surgery

At The Center for Reproductive Medicine and Robotic Surgery we provide private, professional and compassionate fertility care. Dr. Jacob and our reproductive team provide a very personalized approach, from diagnostic assessment and early intervention through high-tech procedures like In Vitro Fertilization (IVF), and Intracytoplasmic Sperm Insertion (ICSI), intrauterine insemination (IUI) and Preimplantation Genetic Diagnosis (PGD). We offer a full range of medical and surgical interventions addressing infertility issues such as Polycystic Ovarian Syndrome (PCOS), endometriosis, genetic issues, male factor infertility, recurrent pregnancy loss, low ovarian reserve and stress management. Our in-house Egg ( Fresh and Frozen) Donor  Program, sperm donor program, embryo donation program, oocyte cryo program and independent andrology laboratory and cryobank offer top quality, confidential and cost-efficient services for our patients. We provide many advanced surgical procedures including robotic surgery, which is performed using the Da Vinci Robotic system which enables surgeons to perform surgical procedures with unmatched precision, dexterity and control.  The patient usually experiences significantly less pain, fewer complications, minimal blood loss, shorter hospital stay, minimal scarring, and a quicker recovery and return to normal activities.

Our medical Director, Dr. Jacob is a certified Robotic Surgeon and is a national proctor. He train surgeons in Robotic Surgery. Dr. Jacob completed his residency in Obstetrics and Gynecology at Washington University School of Medicine in St. Louis and fellowship in Reproductive Endocronology and Infertility at the Royal College of Surgeons, Rotunda Hospital, Dublin.Dr. Jacob is a Clinical Assistant Professor in Obstetrics & Gynecology at Washington Univeristy School of Medicine in St. Louis. He is the Medical and Program Director of the Center.

We are excited to share our 2015 success rates; The overall pregnancy rate was 76% per embryo transfer ( < 35 years - 72%, > 35 years - 80%, egg donor - 100%).

We are located in St. Louis, the heart of the Midwest - only 10 minutes from St. Louis Lambert Field Airport, providing services for patients locally and around the world. We are currently accepting new patients and welcome the opportunity to help you fulfill your dreams of having a child. Call us today for an appointment. phone: 314.473.1285 fax: 314.473.1287

Dr. Saji Jacob


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Ashley Graham

Office Manager

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Become a Donor/Choose a donor
 Infertility Videos

Robtic Microsurgical Tubal reapir

Hysteroscopic resection of uterine septum

Cryopreservation of eggs and embryos

These are videos of actual surgeries. Viewer discretion advised!!!
More Videos>>
 Robotic Surgery Videos

Introduction to CRMRS and simple hysterectomy done using Da Vinci robot


Simple myomectomy using the robot

Complex stage 4 Endometriosis surgery

These are videos of actual surgeries. Viewer discretion advised!!!
Gynecological Testimonial

Forty-three-year-old Stephanie Venable walked out of her gynecologist’s office feeling desperate. She touched her abdomen, which was tender a ...

(336) 621-9772
Infertility Success Story

After 2 years of trying to conceive naturally and without any luck, my husband and I came to Dr. Jacob’s office. We were not sure if we would ev ...

(925) 519-8788